Though the study reported no significant correlation between CTCF and ESRP1 mRNA, given that ESRP1 itself is involved in the regulation of circRNA biogenesis across multiple cancer types including clear cell renal cell carcinoma [151], it is conceivable that circESRP1 and the splicing factor ESRP1 is involved in complex regulatory network that remains unresolved. Here, ESRP1 is linked to cancer.