CD274 and colorectal carcinoma: It is widely reported that MMRd CRC patients are more sensitive in response to anti-programmed death-1 receptor (PD-1)/programmed death-1 receptor ligand 1 (PD-L1) therapy than MMRp patients30–32, consistently, PAS of ‘PD-1 signaling’ pathway in the immature goblet that associated with factor 2 was significantly elevated in MMRd patients (Fig. 3b).