CD8A and systemic lupus erythematosus: Moreover, PAS of “Cross-presentation of particulate exogenous antigens (phagosomes)” was significantly increased in cM (Fig. 6d), which could promote the activation of cytotoxic CD8 + T cells39, correspondingly, PAS of “Granzyme A-mediated apoptosis pathway” was significantly upregulated in T8 of SLE patients (Fig. 6e).