In contrast, there was a significantly smaller proportion of tumours with CRS3 in the germline BRCA1 PV subgroup compared to the germline BRCA1/2 wild type group (OR 0.35, 95% CI 0.14–0.91; P = 0.0291) (Table 4 and Fig. 3). The gene discussed is BRCA1; the disease is neoplasm.