On the other hand, downregulated KEAP1 expression correlates with the phenotype of suppressed cell migration and invasion, causing cell shrinkage due to decreased focal adhesions via an inhibited RhoA-ROCK pathway, as demonstrated by the KEAP1/NRF2 inhibition in non-small-cell lung cancer cells86 as a strategy for treating cancers with high NRF2 activity87. Here, RHOA is linked to cancer.