ELFN1 encodes a protein typically found in the extracellular matrix and is involved in cell adhesion and signaling.35 He et al36 demonstrated that ELFN1-AS1 promotes CRC’s immune escape from NK cells by facilitating the binding of GCN5 and SND1 to GDF15, considering ELFN1-AS1 as a potential therapeutic target for CRC. The gene discussed is GDF15; the disease is colorectal carcinoma.