Understanding the prognosis of CRC is crucial for guiding the direction of selecting appropriate treatment strategies for patients.30 Research has identified a correlation between NETs scores and survival rates in various types of cancer, leading to the development of a pan-cancer prognostic marker centered around NETs.31 In the present study, a prognostic model for CRC was established based on NETs-related DEGs (PRKRIP1, SERTAD2, ELFN1, and LINC00672). Here, SERTAD2 is linked to cancer.