Gastric cancer harbors aberrations in the FGFR2/ErbB3/PI3K pathway or the activated ErbB2/PI3K pathway.18 Moreover, quercetin, targeting ERBB2/ERBB3, can inhibit colon cancer cell growth and induce apoptosis via the Akt pathway.22 This study used network pharmacology analysis and cellular experiments to discover that SD may inhibit the activation of the PI3K/AKT pathway and treat GC by acting on ERBB2 and ERBB3. This evidence concerns the gene ERBB3 and gastric cancer.