Additional inflammation‐associated proteins were raised in sporadic ALS (Scavenger receptor cysteine‐rich type 1 protein M130‐CD163, Complement component C7, and peptidase inhibitor 16), whereas a single protein (latent‐transforming growth factor β‐binding protein 4) was decreased in abundance in C9orf72 ALS. This evidence concerns the gene PI16 and amyotrophic lateral sclerosis.