These proteins were selected before data analysis, based primarily on our previous work comparing the CSF proteome of participants with sporadic ALS with controls, but with additional proteins of interested such as Neuronal pentraxin‐2 (NPTX2) and transmembrane glycoprotein NMB (GPNMB) identified from the literature.13, 20, 26. This evidence concerns the gene NPTX2 and amyotrophic lateral sclerosis.