Genes involved in BCR signaling and B‐cell activation (MYD88, CARD11, TBL1XR1, CD79B, TNFAIP3) or epigenetic regulators (KMT2D, CREBBP, TET2) were observed at frequencies comparable with de novo DLBCL subtypes. The gene discussed is CARD11; the disease is diffuse large B-cell lymphoma.