Adult HGBCL, NOS exhibited higher genomic complexity, like DLBCL, featuring aberrations in key tumor suppressor genes (TSGs) such as PRDM1 (25%), TP53 (24%), CDKN2A (33%), and RB1 (30%), as well as gains in genes with oncogenic function (REL, BCL2, TCF4, MALT1). This evidence concerns the gene REL and diffuse large B-cell lymphoma.