Participants with SLD and any two MetS traits were at greater risk of prevalent CKD (OR 1.53, 95% CI 1.35–1.74, p < 0.0001) when compared to participants without SLD and no MetS traits independently of age, sex, smoking status, ethnicity, risk of advanced liver fibrosis determined by FIB‐4 and PNPLA3 rs738409 genotype (Table 2). The gene discussed is PNPLA3; the disease is metabolic syndrome.