A group of chemoattractant were upregulated in AD patients, including P‐selectin, E‐selectin, ICAM‐1, VCAM‐1, and plasma vesicle associated protein (PLVAP), among which ICAM1 and VCAM1 mediate firm adhesion, P‐selectin, and E‐selectin mediate the rolling of leukocytes along the endothelium, and PLVAP participates in transmigration across ECs [173]. Here, ICAM1 is linked to Alzheimer disease.