For example, in 3 × Tg‐AD mice (Aβ plaques are formed at 6‐month‐old, preceding which cognitive impairment occurs [3–6 months]), ABCA1 are upregulated during 3–6‐month‐old (before Aβ plaques are formed but cognitive impairment occurs) to maintain the equilibrium of Aβ influx and efflux transport against increased Aβ influx due to downregulated LRP1 and upregulated RAGE. The gene discussed is ABCA1; the disease is Cognitive impairment.