ITGAE is associated with a group of genes that have a cytotoxic function in CD8 cytotoxic T cells (CTSW, GNLY, NKG7, PRF1, GZMB, KLRK1) up-regulated in the tumor, identifying resident CD8 T cells in the tumor to have a highly cytotoxic and activated phenotype. The gene discussed is CD8A; the disease is neoplasm.