OLIG2 and Alzheimer disease: To this end, we crossed Bace1fl/fl;Olig2-Cre mice with Bace1fl/fl;AppNL−G−F/wt mice [47] to generate an AD mouse line lacking oligodendrocyte Bace1 (Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt).