Next, to determine the contribution of oligodendrocyte BACE1 to amyloid plaque formation, we generated Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt mice by breeding Bace1fl/fl;Olig2-Cre mice with heterozygous APP knock-in (Bace1fl/fl;AppNL−G−F/wt) AD mice. Here, OLIG2 is linked to Alzheimer disease.