However, mice deficient in NLRP3 and caspase-1 are resistant to P. yoelii YM infection and present lower levels of parasitemia than wild-type mice do, indicating that NLRP3 and caspase-1 inflammasome activation negatively modulates host immune responses to resist lethal P. yoelii YM infection [62]. Here, NLRP3 is linked to parasitic infectious disease.