OXT and autism: In a study of adults with ASD, participants significantly reduced their scores on the Autism Diagnostic Observation Schedule (ADOS)89 after 6 weeks of oxytocin administration,90 though in this case the changes were not significantly increased as compared to single-dose administration.91 In an open-label study, Tachibana et al. administered intranasal oxytocin to a group of eight participants with ASD, increasing the dosage every 2 months.