OXTR and psychiatric disorder: For 70 years, synthetic oxytocin (e.g., Pitocin®) has been used therapeutically, most commonly to augment labor and prevent postpartum hemorrhage.77,78 By the early 1990s, oxytocin was increasingly being used to augment social responses and receptiveness.79 Since then, many studies have examined the impact of exogenous oxytocin on social processing and psychiatric disorders.62,79–85 However, the actions of oxytocin are dependent on its receptor, making an understanding of the mechanisms driving receptor availability, such as OXTR methylation, critical to the field of therapeutics.86