For APOBEC3A, the top ten pathways included those involved in epidermal and keratinocyte development and differentiation, whereas, consistent with observations in bulk RNA-seq data from breast cancer (Cescon et al, 2015), all processes in the top ten for APOBEC3B were associated with mitosis (Fig. 2B; Dataset EV1). This evidence concerns the gene APOBEC3B and breast carcinoma.