The low expression of APOBEC3B in normal epithelium and increased levels in tumours that we observed in scRNA-seq datasets is consistent with previous analyses of bulk tissue samples and breast cancer cell lines (Burns et al, 2013a), in which repressive E2F/RB complexes have been shown to silence expression in quiescent cells (Periyasamy et al, 2017; Roelofs et al, 2023, 2020). The gene discussed is RB1; the disease is breast cancer.