APOBEC3A and neoplasm: Since the Visium platform typically provides resolution of approximately 10 cells / spot depending on cell size and cellularity, we performed spot deconvolution, observing that the APOBEC3A reads from each spot were largely derived from epithelial (tumour) cells with expression also evident in monocytes and neutrophils, consistent with previous reports (Suspène et al, 2011; Aynaud et al, 2012; Chen et al, 2006).