We also observed strong correlations between APOBEC3A and GRHL3 expression (Fig. EV2D), and GRHL3 activity scores (Fig. EV2E) in bulk RNA-seq data from SCCs, and from adenocarcinomas of the cervix (CESC-AD) and oesophagus (ESCA-AD). Here, APOBEC3A is linked to adenocarcinoma.