Although it was not possible to visualise the four phenotypes (basal, proliferating, differentiating and terminally differentiated) on UMAPs due to the cells from individual tumours clustering by patient rather than by phenotype (Appendix Fig. S9E), we again observed APOBEC3A co-expression with markers of differentiation and components of the RIPK4 pathway and APOBEC3B co-expression with markers of proliferation (Appendix Fig. S10A). This evidence concerns the gene APOBEC3B and neoplasm.