Lfng-eGFP;p53fl/fl;Kras;Sox9-CreER showed GFP in metaplastic ductal cells and tumor cells (Fig. 7H, I), whereas Lfng-eGFP;p53fl/fl;Kras pancreas showed no GFP in normal ducts (Fig. 7J). Here, SOX9 is linked to neoplasm.