Moreover, periostin, which is primarily secreted by cardiac fibroblasts after myocardial infarction88, has been shown to induce cardiomyocyte cell cycle reentry and mitosis, and was associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increased angiogenesis after myocardial infarction in mice89. This evidence concerns the gene POSTN and myocardial infarction.