CASP3 and glioma: Pre-treatment of cells with NAC significantly attenuated AMT-induced cleavage of caspase 3 and PARP (Figs. 2G and S3D).The cytotoxicity phenotype was also rescued by NAC in the CCK-8 assay (Figs. 2H and S3E) and colony formation (Figs. 2I, J and S3F, G), which further verified the ROS-induced therapeutic effect of AMT in glioma cells.