PIK3C3 and central nervous system cancer: As depicted in Fig. S2A, B, combination of Z-VAD (an apoptosis inhibitors) or 3-Methyladenine (3-MA, an inhibitor of class III PI3K/Vps34) with AMT abrogated its inhibitory effect on glioma cell proliferation, while ferrostatin-1 (Fer-1, an effective and selective inhibitor of ferroptosis) exhibited no significant effect.