MDM2 and non-small cell lung carcinoma: As shown in Fig. 6F, the expression of FOXO3a was markedly increased, whereas the levels of FOXM1, MDM2 and RAD51 were significantly decreased in SPIN1-deficient cells, further suggesting that SPIN1 may be integral to the regulation of the FOXO3a/FOXM1 axis in NSCLC cells.