RHPN2 and hepatocellular carcinoma: RHPN2 (rhophilin Rho GTPase binding protein 2), encoding a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins, is frequently mutated in several cancer types, such as lung cancer [34], hepatocellular carcinoma [35], and ovarian cancer [36].