Conversely, SPARCL1 was found to be upregulated in kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC) (p < 0.001), and cholangiocarcinoma (CHOL) (p < 0.01). The gene discussed is SPARCL1; the disease is cholangiocarcinoma.