The risk of dementia was lower in those recruited since 2016 after controlling for sex (model 1: HR 0.38, 95% CI 0.17 to 0.85, p=0.019); after further adjusting for EGFr site (model 2: HR 0.41; 95% CI 0.18 to 0.93; p=0.032); vascular risk factors (model 3: HR 0.39; 95% CI 0.17 to 0.87; p=0.021) and mutation site and vascular risk factors (model 4: HR 0.43; 95% CI 0.19 to 0.99; p=0.046). This evidence concerns the gene EGFR and dementia.