In the fully adjusted model 4, current smoking (HR 2.09; 95% CI 1.56 to 2.82; p<0.001), male sex (HR 1.61; 95% CI 1.25 to 2.06; p<0.001) and EGFr domain 1–6 (HR 1.64; 95% CI 1.18 to 1.30; p=0.004) were predictors of younger age at first stroke. This evidence concerns the gene EGFR and stroke disorder.