Similarly, the increased migration persistence we observed in vinculin KO MCF10A cells is in contrast to the decreased persistence observed upon vinculin depletion in MEF KO cells or siRNA-treated mammary carcinoma MDA-MB-231 cells, using different assays (Thievessen et al, 2015; Rahman et al, 2016; Lee et al, 2019). The gene discussed is VCL; the disease is breast carcinoma.