SELE and adenocarcinoma: In sharp contrast, tumor cells with detectable sLeA/X expression, such as gastrointestinal (GI) adenocarcinomas, bind E-selectin with high affinity, even in the absence of shear stress; in case of these tumors, the bortezomib -mediated reduction in E-selectin was neither sufficient to impair endothelial adhesion in vitro nor to reduce spontaneous metastasis in vivo [8].