Therefore, it is likely that a modified release preparation would be required similar to those already developed for hydrocortisone.14,45 If proven to be a metabolically safer glucocorticoid than current options, corticosterone could be used either as monotherapy or in combination with other novel approaches to reduce androgens such as antagonists to CRFR1 or the ACTH receptor.1 In addition, corticosterone could be used to treat other causes of primary and secondary adrenal insufficiency. Here, CRHR1 is linked to Adrenal insufficiency.