PTPRD and Global developmental delay: In addition, the remaining SNPs showed evidence in synaptic activity of the brain, including an intron variant of CACNA1A (rs73922613), which encoded a subunit of neuronal calcium channel (33) and was involved in a broad phenotypic spectrum of early developmental delay (34) and neuropsychiatric disorders (35), an intron variant of PTPRD (rs55829244) encoding a neuronal cell adhesion molecule and synaptic specifier, and a variant mapped to CDH11 (rs3964317) that correlated with altered dendritic complexity and neuronal/synaptic activity (36).