IL6 and cancer: For another two SNPs, rs1423687 was functionally mapped to OSMR involved in cytokine signaling, especially the interleukin-6 (IL-6) family (28, 29), and rs7372321 was an intro variant of ADAMTS9-AS2, which was widely studied in human cancers due to its relationship with the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway (30, 31) implicated in inflammation (32).