To summarize, we firstly revealed a miRNA-mRNA network, comprising 5 miRNAs: miR-24-3p, miR-23b-3p, miR-130a-3p, miR-324-5p, miR-497-5p, and 10 genes: E2F2, HMGB2, LDHA, UBE2C, LMNB1, CEP55, AHNAK, AKT3, PLAG1, PLEKHA1, shared between AP and EBV infection, which may help to identify novel diagnostic biomarkers and therapeutic targets in clinical practice. The gene discussed is PLEKHA1; the disease is alkaline phosphatase measurement.