BIRC5 and colorectal carcinoma: Furthermore, the RNA levels of several downstream transcriptional targets such as CD44, Oct3/4, Survivin and Axin2 were decreased by miR-145 whereas they were increased by anti-miR-145 (Fig 2N and 2O), indicating that miR-145 suppressed the activation of Wnt/β-catenin pathway in CRC cells.