Amongst other possible follow up investigations to our study such as assessing vitamin D and E in association with ApoA-I priming for improving insulin secretion to both treat diabetes and prevent diabetes complications [53, 54], a suggested starting point is to silence both SR-BI and ABCA1 simultaneously and examine INS-IE mitochondrial function and insulin secretion to investigate diminished effects and possible compensatory mechanisms. This evidence concerns the gene APOA1 and diabetes mellitus.