The final risk factors for OS in both the training group and all patients with advanced stage CRC were identified as age (≥ 60), location (colon), TNM (IV), chemotherapy (no), liver metastasis (yes), lung metastasis (yes), MSH6 (negative), CEA (high), CA199 (high), CA125 (high), CA724 (high). This evidence concerns the gene MSH6 and colorectal carcinoma.