TLR2 and Parkinson disease: Furthermore, TLR2 deficiency also increased the abundance of the protective genus Prevotellaceae and decreased the abundance of the genera Oscillospira, Anaerotruncus, Lachnoclostridium, and Helicobacter, which were associated with intestinal inflammation, implying that alterations of the gut microbiota in TLR2-deficient mice may contribute to the recovery of PD pathology [29].