TLR4 and Parkinson disease: However, deletion of TLR4 leaded to a ‘pro-inflammatory’ dysbiotic microbiota, including decreased relative abundance of the anti-inflammatory genera Bifidobacterium and/or Lactobacillus and increased relative abundance of the pro-inflammatory intestinal bacterial genera unclassified Rickettsia, Coccidioides, and Lactobacillus, which may be the reason that TLR4 deficiency could not completely protect against rotenone-induced PD pathology [30].