Recent work suggests that microglia regulate the transition of amyloid pathology to tau pathology [32, 33] via genes expressed by the amyloid-responsive microglial state (ARM) or the disease-associated microglial state (DAM)[27, 37, 41, 54]; cell states that are enriched in dementia and driven by genes including APOE and TREM2. Here, MAPT is linked to dementia.