Based on the finding that ITM2B/BRI2 expression is enriched in microglia, we sought to investigate the pathological contribution of microglia in mutant ITM2B/BRI2-associated post-mortem hippocampal tissue from one FBD case (Case 5 from Holton et al. 2001) and one FDD case (Case 3 from Holton et al. 2002). Here, ITM2B is linked to ABri amyloidosis.