The key findings of the present longitudinal observational study can be summarized as follows: NTproBNPZlog (T1 + T2) and ET-1 (T1) were identified as early predictive biomarkers (DOL 7 and DOL 28) for the combined endpoint BPD/death in VLBW-infants in the univariate analysis. Here, EDN1 is linked to bronchopulmonary dysplasia.