PHC1 and PCGF3 were downregulated in LEPs and breast tissues of older women; these genes showed breast cancer subtype-specific expression, and PHC1 was downregulated in PAM50 LumB and Her2 tumors relative to their matched normal tissue (Figure 5—figure supplement 2Aiv-v and Biv-v). Here, ERBB2 is linked to breast cancer.