Moreover, we found that for primary tumors that had matched normal tissue in TCGA (n=114 tumor and n=109 normal), SATB1 was significantly downregulated in PAM50 LumA, LumB and Her2 breast cancers relative to their matched normal tissue (Figure 5—figure supplement 1B), suggesting further SATB1 dysregulation during cancer initiation. This evidence concerns the gene ERBB2 and neoplasm.