These genes also showed breast cancer subtype-specific expression, and BCL11A and ZNF521, like SATB1, were downregulated in PAM50 LumA, LumB, and Her2 tumors relative to PAM50 Basal tumors and compared to their matched normal tissue (Figure 5—figure supplement 2i-iii and Bi-iii). This evidence concerns the gene SATB1 and breast cancer.