BRCA1 and cancer: Distribution of signature scores showing enrichment of age-dependent DE genes (D) upregulated (left) or downregulated in old LEPs across cell types and between premenopausal and menopausal women via (Pal et al., 2021); (E) upregulated in old LEPs between women with cancer who received chemotherapy and those that did not (left), or downregulated in old LEPs between non-tumorigenic BRCA1 mutation carriers and non-carriers (right) via (Nee et al., 2023); and (F) upregulated in old LEPs between parous and nulliparous (left), or obese and nonobese (right) individuals via (Murrow et al., 2022).