Moreover, based on our analysis of the relative contribution of the identified LEP-derived aging-associated DE and DV genes to the predictive model of breast cancer subtypes, we found DV genes to be strong predictors of PAM50 LumA, LumB and Her2 subtypes but held no strong predictive value for PAM50 Basal subtypes. The gene discussed is TMEM43; the disease is breast carcinoma.