Currently, more than 100 cadherins are identified, which are categorized into four groups, namely classical cadherins, protocadherins, desmosomal cadherins, and cadherin-related proteins.5 Increasing evidence suggests that an imbalance in cadherin expression caused by gene alterations can lead to tumor growth, invasion, and metastasis.6,7 Cadherin 2 (CDH2, N-cadherin) is a member of the classical cadherin group that maintains the integrity of cells and participates in many signal transduction pathways. The gene discussed is CDH2; the disease is neoplasm.