Abnormalities in CDH13 have been observed in many types of human malignant tumors.10 Recently, CDH13 has been shown to play a role as an anticancer gene in lung, breast, ovary, bladder, and gastric cancer.11,12 Abnormal expression of CDH13 plays a key role in cancer development by promoting the inactivation of tumor suppressor genes, activation of oncogenes, and increasing chromosome instability.13 This evidence concerns the gene CDH13 and cancer.