Cotransplantation of shIgf2 CAFs with mammary tumor cell 4T1 or colorectal cancer CT26 cells into BALB/c mice led to a marked increase in CD8+ T cell infiltration and a reduction in tumor growth when compared with the cotransplantation of control CAFs with cancer cells (Supplemental Figure 4, E and F). The gene discussed is CD8A; the disease is breast cancer.