Inoculation of EO771 tumor cells, MC38 tumor cells, and B16-F10 melanoma cells into Igf2-cKO mice revealed increased T cell infiltration and retarded tumor burden compared with that seen in WT mice, similar to Igf2–/– mice (Figure 2, C and D, and Supplemental Figure 4B). This evidence concerns the gene IGF2 and neoplasm.