Remarkably, the suppression of tumor growth in Igf2-cKO or Igf2–/– mice was opposed by the removal of CD8+ T cells using anti-CD8 antibodies (Figure 2E andSupplemental Figure 4C), indicating that the enhanced antitumor activity by IGF2 blockade in CAFs depended on CD8+ T cells. Here, IGF2 is linked to neoplasm.