ASXL1 and chronic myelomonocytic leukemia: The recently identified role of the chromatin regulator additional sex combs-like 1 (ASXL1) in neutrophil development, based on the neutrophilic dysplasia observed in an Asxl1-truncated zebrafish model (44) and the altered transcription program depicted in Asxl1-mutated mouse granulocyte progenitors (45), may account for the correlation between iGRAN excess and ASXL1 gene mutation in CMML patients, both events being associated with a poor outcome (4, 19, 24–27).