CXCL8 and chronic myelomonocytic leukemia: Then we measured the plasma levels of 44 cytokines and chemokines in iGRAN-low (n = 23) and iGRAN-high (n = 26) CMML patients and found that CXCL8 was the cytokine present at the highest level in the plasma of iGRAN-high CMML patients (Figure 5D).