Although LA treatment repressed tumor growth (Figure 5A), reduced tumor weight (Figure 5B), and improved survival (Figure 5C) in nude mice bearing Hepa-1-6 tumors, AMPKα loss ablated this antitumor effect of LA, indicating that the antitumor function of LA requires nuclear PD-L1 compartmentalization in the absence of T cells. Here, CD274 is linked to neoplasm.