Normally, PD-L1 acts as an inhibitory immune checkpoint on the cell membrane to suppress the activity of cytotoxic lymphocytes; nonetheless, in response to stimuli such as LA, PD-L1 protein translocates into the nucleus to activate genes of cellular senescence, JAK/STAT, and Hippo signaling pathways to suppress tumor malignancy and sensitize tumor cells to ICB. The gene discussed is CD274; the disease is neoplasm.