Moreover, increased IFNGR expression by nPD-L1 was also observed (Figure 9, D and E), and subsequently, nPD-L1 dramatically increased the expression of p-STAT1 in Hep3B cells compared with vector in response to IFN-γ, indicating the enhanced IFN-γ response of tumor cells (Figure 9F). The gene discussed is STAT1; the disease is neoplasm.