TMEM119 and central nervous system cancer: To determine whether knockdown of Cbx3 in murine glioma cell lines regulates phagocytosis, we collected the brains from mice bearing luciferase-expressing CT2A tumors and assayed phagocytosis with flow cytometry, using anti-luciferase antibody to detect tumor cells and antibodies against microglial markers CD11b and Tmem119, showing that knockdown of murine Cbx3 in CT2A cells increased phagocytosis (Supplemental Figure 7, G–J).