Despite the presence of immune cells, GBM cells in necrotic regions evade clearance by phagocytes, including microglia and macrophages, through multiple mechanisms, including M2 polarization of phagocytes (7) and interaction between the “don’t eat me” CD47 membrane protein on tumor cells and signal regulatory protein α (SIRPα) on phagocytes (8). This evidence concerns the gene CD47 and glioblastoma.