In SYCP2 (synaptonemal complex protein 2), analysis of the exome of patient 1954 (Egyptian), with 4 CHMs and 2 years of primary and secondary infertility (before the first and after the third HM), identified a variant affecting the canonical acceptor splice site of exon 27, NM_014258.4:c.2530-2A>G, in a homozygous state (Figure 2 and Supplemental Figure 5). This evidence concerns the gene SYCP2 and Infertility.