In MAJIN (membrane-anchored junction protein), analysis of the exome of patient 1824 (Italian), with 2 HMs followed by secondary infertility and substantially reduced bilateral ovarian volumes (1.1 cm3 and 2.5 cm3 at the age of 25 years as compared with the normal volume, 6.1 cm3 in women under the age of 30 years), revealed a novel variant affecting the splice donor of exon 6, NM_001037225.3:c.349+1G>T, in a homozygous state and located in an ROH of 48.3 Mb (Figure 1 and Supplemental Figure 3). This evidence concerns the gene MAJIN and Infertility.