Subsequently, to explore the mechanism by which MDSCs utilize PTX-Rg3-lipo, publicly available single-cell RNA sequencing (scRNA-Seq) data from patients with CRC were used to determine the expression levels of the glucose transporter isoforms GLUT1, GLUT2, GLUT3, and GLUT4 in various compartments of the tumor microenvironment. This evidence concerns the gene SLC2A4 and neoplasm.