Since a crucial physiological function of vWF is to act as a carrier for factor VIII to protect it from early proteolytic degradation, these complexes are used for the treatment of vWD and Hemophilia A as vWF reduces the immunogenicity of FVIII.53, 54, 55, 56, 57. The gene discussed is VWF; the disease is von Willebrand disease (hereditary or acquired).