On the other hand, given that the DAPK-tau interaction mediates synaptic damage (Pei et al., 2015) in stroke and that DAPK-NDRG2 interplay drives neuronal apoptosis in AD (You et al., 2017), DAPK overactivation may also drive these two pathological changes in seizure-induced exacerbation of AD. This evidence concerns the gene MAPT and Alzheimer disease.