BACE1 and Seizure: Since eIF2a and eIF4B phosphorylation positively regulate BACE1 mRNA levels (O'Connor et al., 2008; Bettegazzi et al., 2021) and PERK-mediated phosphorylation of eIF2a is induced in TLE (Gourmaud et al., 2020), epileptic seizures might increase BACE1 mRNA levels via eIF2a phosphorylation.