DAPK1 and Alzheimer disease: Considering that DAPK is a downstream signaling molecule of ERK (Chen et al., 2005) and that both DAPK and ERK play similar roles in AD and epilepsy (Chun et al., 2022; Nateri et al., 2007), we hypothesized that seizure-induced exacerbation of AD may involve dysregulation of the ERK‒DAPK pathway.