One potential link between TLE and AD is extracellular regulated kinase (ERK)-death-associated protein kinase (DAPK) axis, which has been reported to be overactivated in patients with TLE and AD (Gan et al., 2022; Gan et al., 2021; You et al., 2017; Chun et al., 2022; Ephrame et al., 2023). This evidence concerns the gene DAPK1 and Alzheimer disease.