DAPK1 and Alzheimer disease: To investigate whether CBZ can alleviate seizure-induced increases in AD-like neuropathology through the ERK-DAPK pathway, 8-month-old kindled 5×FAD mice were injected i.p. with 20 mg/kg CBZ or vehicle (10% DMSO) every other day (15 injections for 4 weeks) and brain tissues were collected at the indicated time point.