Since DAPK phosphorylates tau at Ser262 (Pei et al., 2015), MAPK phosphorylates tau at Ser202/Thr205 (Drewes et al., 1992), and ERK is a downstream target of MAPK, more studies are needed in the future to clarify the regulatory relationships between the ERK‒DAPK axis and the hyperphosphorylation of tau at different loci in epileptic AD mice. Here, DAPK1 is linked to Alzheimer disease.