These genes were enriched in 40 GO terms, primarily related to immune-inflammatory response regulation (Supplementary Table S6), and in 10 KEGG signaling pathways, including Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Cell cycle, Cushing syndrome, Chemokine signaling pathway, Toll-like receptor signaling pathway, Viral carcinogenesis, Human cytomegalovirus infection, Cytokine-cytokine receptor interaction, and DNA replication (Supplementary Table S6; Figure 4E). Here, TNF is linked to Cushing syndrome due to macronodular adrenal hyperplasia.