MAPT and Alzheimer disease: In recent decades, significant advancements have been made in understanding the pathology of AD, including amyloid beta (Aβ) deposition and plaque (Depp et al., 2023), neurofibrillary tangles of abnormally phosphorylated Tau protein (Wegmann et al., 2021), neuroinflammation, oxidative stress, neuronal loss, synaptic dysfunction (Jack et al., 2024; Scheltens et al., 2021).