In diabetes, hyperglycemia can stimulate the activation of NLRP3, thus activate Caspase-1, which can promote the maturation of cytokines pro-IL-1β and pro-IL-18 to release the cleaved fragments of active IL-1β and IL-18, and lead to pyroptosis (Abderrazak et al., 2015). Here, IL18 is linked to Hyperglycemia.