ATP6AP2 and familial dilated cardiomyopathy: Next, we measured heart function of DCM rats, and found a significant improvement of LVEF and E/A ratio and decrease of LVESD and LVEDD in the Ad-PRR-shRNA group compared the Ad-SC-shRNA group, while no significant change was observed in the DCM group compared with the Ad-SC-shRNA group (Figures 7F–J).