The results showed the arrangement of myocardial tissue in the DCM group was sparse and slightly disordered compared with Control group, and after the overexpression of PRR, the arrangement of myocardial tissue was more disordered, but there was no statistical significance between the DCM group and Ad-EGFP group (Figure 5A). This evidence concerns the gene ATP6AP2 and familial dilated cardiomyopathy.