IRF3 and cardiomyopathy: For example, Li et al. demonstrated that NLRP3 activated by STING-IRF3 is involved in lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis, and pyroptosis, they found that STING binds to type I interferon (IFN) regulatory factor 3 (IRF3) and phosphorylates it, thereby promoting the activation of NLRP3 and aggravating pyroptosis of sepsis-induced cardiomyopathy (Li et al., 2019).