CH25H and diabetes mellitus: In people with diabetes, plasma levels of the preproducts of 7α,25-OHC and 7α,27-OHC; 25-hydroxycholesterol (25-OHC), 27-hydroxycholesterol (27-OHC), together with visceral adipose tissue (VAT)-expressed cholesterol 25-hydroxylase (CH25H), are increased compared to individuals without diabetes [12-14].