Intriguingly, increased plasma levels of 25-OHC and 27-OHC (preproducts of 7α,25-OHC and 7α,27-OHC) have been described in people with diabetes [12-14], and 7α,25-OH protects human islets against glucotoxicity-induced β-cell damage, as well as potentiate insulin secretion [25]. This evidence concerns the gene INS and diabetes mellitus.