During the early stage of AMD, a dry AMD-specific activated microglia cluster appeared with upregulation of APOE, TYROBP, and SPP1, while cell type-specific transcriptional changes exclusively in the subcluster of microglia in late-stage neovascular AMD displayed an inflammasome-related signature including IL1B, NOD2, and NFKB1. The gene discussed is IL1B; the disease is age-related macular degeneration.