The inflammasome sensor AIM2 has been identified as a susceptibility gene locus for psoriasis, closely associated with the genetic and epigenetic factors of the disease, with increased expression in psoriatic keratinocytes (112); a recent study found significant upregulation of DNA sensors ZBP1, the NLRP3 inflammasome, and cGAS/STING, along with IFN signaling molecules (IFN-β, IFN-γ, and TNF-α) in colonocytes from active UC patients (98). This evidence concerns the gene TNF and psoriasis.