In a septic mouse model induced by cecal ligation and perforation (CLP), sepsis caused intestinal injury with disrupted mucosal structure, increased intestinal ischemia–reperfusion injury, increased plasma diaminooxidase (DAO) and intestinal-type fatty acid-binding (FABP2) protein levels, and decreased AQP3 and occludin expression. Here, AQP3 is linked to Sepsis.