AQP2 and acute kidney injury: Another study explored the impact of miR-34b-5p on sepsis-induced injury in human renal tubular epithelial cells, revealing that elevated miR-34b-5p levels in septic acute kidney injury (AKI) patients correlated with inflammation and apoptosis through downregulation of AQP2, a direct target of miR-34b-5p, exacerbating injury when overexpressed and mitigated by inhibiting miR-34b-5p or enhancing AQP2 expression Another study investigated the influence of miR-34b-5p on sepsis-induced injury in human renal tubular epithelial cells.