Similarly, tumor-specific loss of p53 delayed tumor rejection in a cell-extrinsic manner by inducing CXCL11, CXCL1, CXCL5, CCL3, and M-CSF expression to promote the recruitment of MDSCs and T reg, which were found to attenuate both CD4+ and CD8+ T cell activation (288). The gene discussed is CD8A; the disease is neoplasm.