In comparison to cancers with low CNAs, highly aneuploid tumors are characterized by reduced inflammatory signatures, reduced gene expression of cytotoxic lymphocytes, including T and NK cells, and lower ratios of CD8/T reg and anti-tumor M1/pro-tumor M2 macrophages, indicative of a more immunosuppressive TME (59, 61, 152). The gene discussed is CD8A; the disease is neoplasm.