IFNA1 and cervical squamous intraepithelial neoplasia: Downregulation of IFN signaling, and the antigen presentation machinery was observed during the evolution of high CIN tumors in immunocompetent hosts, but not in immunodeficient (61) and human CRCs with high CIN scores generally show lower expression of MHC-I in comparison to other CRC subtypes (152) (Figure 5).