TNF and cancer: Loss of the 9p21 locus has been widely associated with reduced JAK/STAT, TNFα, and NF-κB signatures, as well as with reduced expression of CXCL9 and CXCL10 chemokines, reduced CD3+ and CD8+ T cell infiltration, and, importantly, with poor prognosis and increased resistance to ICB in several cancer types (209, 233, 273, 274).