CXCL13 and neoplasm: In comparison to the 3 other CMS, the MMRd-enriched subgroup shows significantly higher infiltration scores of cytotoxic lymphocytes and Th1 cells, low infiltration of regulatory T cells, and high expression of genes encoding for cytotoxic T cell attracting chemokines, Th1 cytokines, and other cytokines and chemokines involved in anti-tumor immunity such as IFNs, CXCL13 and IL15 (43, 152).